Gastrin regulates the TFF2 promoter through gastrin-responsive cis-acting elements and multiple signaling pathways

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Gastrin regulates the TFF2 promoter through gastrin-responsive cis-acting elements and multiple signaling pathways.

Trefoil family factor 2 (TFF2) is expressed in gastrointestinal epithelial cells where it serves to maintain mucosal integrity and promote epithelial repair. The peptide hormone, gastrin, stimulates acid secretion but also induces proliferation of the acid-secreting mucosa. Because the relationship between these peptides of overlapping function is not understood, we chose to investigate the reg...

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ژورنال

عنوان ژورنال: American Journal of Physiology-Gastrointestinal and Liver Physiology

سال: 2007

ISSN: 0193-1857,1522-1547

DOI: 10.1152/ajpgi.00348.2006